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Article

Genomic characterization of primary central nervous system lymphoma.

Acta neuropathologica - 1 Jun 2016

Fukumura Kazutaka, Kawazu Masahito, Kojima Shinya, Ueno Toshihide, Sai Eirin, Soda Manabu, Ueda Hiroki, Yasuda Takahiko, Yamaguchi Hiroyuki, Lee Jeunghun, Shishido-Hara Yukiko, Sasaki Atsushi, Shirahata Mitsuaki, Mishima Kazuhiko, Ichimura Koichi, Mukasa Akitake, Narita Yoshitaka, Saito Nobuhito, Aburatani Hiroyuki, Nishikawa Ryo, Nagane Motoo, Mano Hiroyuki

Abstract excerpt

Primary central nervous system lymphoma (PCNSL) is a rare malignancy confined to the central nervous system (CNS), and majority of PCNSL is pathologically classified as diffuse large B-cell lymphoma (DLBCL). We have now performed whole-exome sequencing for 41 tumor tissues of DLBCL-type PCNSL and paired normal specimens and also RNA-sequencing for 30 tumors, revealing a very high frequency of nonsynonymous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 26757737
DOI: 10.1007/s00401-016-1536-2

Genes

MYD88
BTG2
GRB2
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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