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Article

Mutational analysis of primary central nervous system lymphoma.

Oncotarget - 15 Jul 2014

Bruno Aurélie, Boisselier Blandine, Labreche Karim, Marie Yannick, Polivka Marc, Jouvet Anne, Adam Clovis, Figarella-Branger Dominique, Miquel Catherine, Eimer Sandrine, Houillier Caroline, Soussain Carole, Mokhtari Karima, Daveau Romain, Hoang-Xuan Khê

Abstract excerpt

Little is known about the genomic basis of primary central nervous system lymphoma (PCNSL) tumorigenesis. To investigate the mutational profile of PCNSL, we analyzed nine paired tumor and germline DNA samples from PCNSL patients by high throughput exome sequencing. Eight genes of interest have been further investigated by focused resequencing in 28 additional PCNSL tumors to better estimate their incidence. Our...

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Share to B-Lymphocytes
Share to Central Nervous System Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Genetic Predisposition to Disease

Share to INDEL Mutation

Share to Lymphoma, Large B-Cell, Diffuse

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 24970810
DOI: 10.18632/oncotarget.2080
PMCID: PMC4148122

Genes

EBF1
ETV6
MYD88
PIM1

Provenance

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