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Article

Whole-Exome Sequencing Revealed the Mutational Profiles of Primary Central Nervous System Lymphoma.

Clinical lymphoma, myeloma & leukemia - 1 Apr 2023

Zhang Rui, Wei Boyuan, Hu Yiyang, Lv Wenying, Adilai Abudurexiti, Yang Fan, Zhang Jianning, Cheng Gang

Abstract excerpt

BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a highly aggressive type of extranodal non-Hodgkin lymphoma, of which approximately 90% of the cases are diffuse large B-cell lymphoma (DLBCL). In recent years, the incidence of PCNSL has significantly increased in women and older men. Although advanced treatments such as high-dose methotrexate (HD-MTX) and targeted agents have been introduced, the...

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Identifiers

PMID: 36725383
DOI: 10.1016/j.clml.2023.01.003

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