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Article

Genomic landscape and molecular subtypes of primary central nervous system lymphoma.

Blood cancer journal - 26 Nov 2025

Li Shengjie, Li Danhui, Xia Zuguang, Wu Jianing, Ren Jun, Li Yingzhu, Cao Jiazhen, Sun Ying, Li Chengxun, Cao Wenjun, Mao Ying

Abstract excerpt

The genetic landscape and molecular subtypes of primary central nervous system lymphoma (PCNSL) remain inadequately characterized, presenting a major obstacle to the development of effective therapeutic strategies. We conducted a genomic study of 176 PCNSLs from five tertiary centers with long-term follow-up to expand the genomic landscape and identify new molecular subtypes. We first confirmed that the molecular...

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Identifiers

PMID: 41298346
DOI: 10.1038/s41408-025-01421-7
PMCID: PMC12783669

Genes

EP300
BTG1
MYD88

Provenance

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