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Article

Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2015

Braggio Esteban, Van Wier Scott, Ojha Juhi, McPhail Ellen, Asmann Yan W, Egan Jan, da Silva Jackline Ayres, Schiff David, Lopes M Beatriz, Decker Paul A, Valdez Riccardo, Tibes Raoul, Eckloff Bruce, Witzig Thomas E, Stewart A Keith, Fonseca Rafael, O'Neill Brian Patrick

Abstract excerpt

PURPOSE: Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma confined to the central nervous system. Whether there is a PCNSL-specific genomic signature and, if so, how it differs from systemic diffuse large B-cell lymphoma (DLBCL) is uncertain. EXPERIMENTAL DESIGN: We performed a comprehensive genomic study of tumor samples from 19 immunocompetent PCNSL patients. Testing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 6

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Source

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Identifiers

PMID: 25991819
DOI: 10.1158/1078-0432.CCR-14-2116
PMCID: PMC4558226

Genes

PRKCD
TOX
B2M
BCL6
CARD11
CD58
CD79B
CDKN2A
GNA13
MYD88
PRDM1
TBL1XR1
TNFAIP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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