Article
Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis.
Shock (Augusta, Ga.) - 1 Sept 2008
Wheeler Derek S, Lahni Patrick M, Denenberg Alvin G, Poynter Sue E, Wong Hector R, Cook James A, Zingarelli Basilia
Abstract excerpt
The fundamental mechanisms that underlie endotoxin tolerance remain to be elucidated, and the clinical significance of endotoxin tolerance in the context of active systemic infection remains in question. We hypothesized that the endotoxin tolerance phenotype would result in decreased inflammation at the expense of altered bacterial clearance and, thus, higher mortality in a murine model of polymicrobial sepsis...
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