Article
Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells.
Scientific reports - 11 Jan 2016
Morata-Tarifa Cynthia, Jiménez Gema, García María A, Entrena José M, Griñán-Lisón Carmen, Aguilera Margarita, Picon-Ruiz Manuel, Marchal Juan A
Abstract excerpt
Cancer stem cells are responsible for tumor progression, metastasis, therapy resistance and cancer recurrence, doing their identification and isolation of special relevance. Here we show that low adherent breast and colon cancer cells subpopulations have stem-like properties. Our results demonstrate that trypsin-sensitive (TS) breast and colon cancer cells subpopulations show increased ALDH activity, higher...
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