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Article

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors.

Journal of visualized experiments : JoVE - 1 Mar 2020

Laranjo Mafalda, Carvalho Maria João, Serambeque Beatriz, Alves André, Marto Carlos Miguel, Silva Isabel, Paiva Artur, Botelho Maria Filomena

Abstract excerpt

Cancer stem cells (CSC) are a small population with self-renewal and plasticity which are responsible for tumorigenesis, resistance to treatment and recurrent disease. This population can be identified by surface markers, enzymatic activity and a functional profile. These approaches per se are limited, due to phenotypic heterogeneity and CSC plasticity. Here, we update the sphere-forming protocol to obtain CSC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32176214
DOI: 10.3791/60022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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