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Brca1 breast tumors contain distinct CD44+/CD24- and CD133+cells with cancer stem cell characteristics

1 Feb 2008

Abstract excerpt

INTRODUCTION: Whether cancer stem cells occur in BRCA1-associated breast cancer and contribute to therapeutic response is not known. METHODS: We generated and characterized 16 cell lines from five distinct Brca1deficient mouse mammary tumors with respect to their cancer stem cell characteristics. RESULTS: All cell lines derived from one tumor included increased numbers of CD44+/CD24- cells, which were previously...

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PMID: 18241344
DOI: 10.1186/bcr1855

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