Article
Serine 363 of the {delta}-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands.
Journal of cell science - 15 Dec 2010
Xu Chi, Hong Min-Hua, Zhang Le-Sha, Hou Yuan-Yuan, Wang Yu-Hua, Wang Fei-Fei, Chen Yue-Jun, Xu Xue-Jun, Chen Jie, Xie Xin, Ma Lan, Chi Zhi-Qiang, Liu Jing-Gen
Abstract excerpt
Distinct opioid receptor agonists have been proved to induce differential patterns of ERK activation, but the underlying mechanisms remain unclear. Here, we report that Ser363 in the δ-opioid receptor (δOR) determines the different abilities of the δOR agonists DPDPE and TIPP to activate ERK by G-protein- or β-arrestin-dependent pathways. Although both DPDPE and TIPP activated ERK1/2, they showed different...
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