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Article

Channelopathy-related SCN10A gene variants predict cerebellar dysfunction in multiple sclerosis.

Neurology - 2 Feb 2016

Roostaei Tina, Sadaghiani Shokufeh, Park Min Tae M, Mashhadi Rahil, Nazeri Aria, Noshad Sina, Salehi Mohammad Javad, Naghibzadeh Maryam, Moghadasi Abdorreza Naser, Owji Mahsa, Doosti Rozita, Taheri Amir Pejman Hashemi, Rad Ali Shakouri, Azimi Amirreza, Chakravarty M Mallar, Voineskos Aristotle N, Nazeri Arash, Sahraian Mohammad Ali

Abstract excerpt

OBJECTIVE: To determine the motor-behavioral and neural correlates of putative functional common variants in the sodium-channel NaV1.8 encoding gene (SCN10A) in vivo in patients with multiple sclerosis (MS). METHODS: We recruited 161 patients with relapsing-onset MS and 94 demographically comparable healthy participants. All patients with MS underwent structural MRI and clinical examinations (Expanded Disability...

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Identifiers

PMID: 26740675
DOI: 10.1212/WNL.0000000000002326
PMCID: PMC4773947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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