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Article

Genotype and Age at Onset Drive Vermis Atrophy in CACNA1A- and GAA-FGF14-related Ataxias.

Cerebellum (London, England) - 4 Mar 2026

Indelicato Elisabetta, Nachbauer Wolfgang, Amprosi Matthias, Pellerin David, Mangesius Stephanie, Gizewski Elke R, Kiechl Stefan, Brais Bernhard, Boesch Sylvia, Krismer Florian

Abstract excerpt

CACNA1A- and GAA-FGF14-related channelopathies are among the most frequent genetic etiologies of cerebellar ataxia. They display overlapping features consisting of both chronic and episodic neurological symptoms and usually show only a mild cerebellar atrophy in imaging studies, with prevalent involvement of the vermis. To evaluate cerebellar volumetry as a biomarker for distinguishing between these disorders and...

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Source

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Identifiers

PMID: 41775907
DOI: 10.1007/s12311-026-01966-8
PMCID: PMC12956909

Genes

CACNA1A
FGF14
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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