Article
Genetic Variants and Multiple Sclerosis Risk Gene SLC9A9 Expression in Distinct Human Brain Regions.
Molecular neurobiology - 1 Nov 2017
Liu Guiyou, Zhang Fang, Hu Yang, Jiang Yongshuai, Gong Zhongying, Liu Shoufeng, Chen Xiuju, Jiang Qinghua, Hao Junwei
Abstract excerpt
A recent genome-wide association study reported a significant association between rs9828519 (G) and nonresponsiveness to interferon-beta (IFN-β) treatment and dysregulation of SLC9A9 expression in multiple sclerosis (MS) cases. We hypothesize that disease-relevant tissues are necessary to detect the effects of rs9828519-tagged SNPs on SLC9A9 expression. Here, we investigated whether SLC9A9 expression is regulated...
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