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Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal<i>Oas</i>Gene Expression and Independent of Virus-Induced Interferon

7 Jan 2016

Abstract excerpt

UNLABELLED: The oligoadenylate synthetase (OAS)-RNase L pathway is a potent interferon (IFN)-induced antiviral activity. Upon sensing double-stranded RNA, OAS produces 2',5'-oligoadenylates (2-5A), which activate RNase L. Murine coronavirus (mouse hepatitis virus [MHV]) nonstructural protein 2 (ns2) is a 2',5'-phosphodiesterase (PDE) that cleaves 2-5A, thereby antagonizing RNase L activation. PDE activity is...

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PMID: 26739051
DOI: 10.1128/jvi.03036-15

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