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Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation

30 Mar 2016

Abstract excerpt

UNLABELLED: Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. Like many coronaviruses, MERS-CoV carries genes that encode multiple accessory proteins that are not required for replication of the genome but are likely involved in pathogenesis. Evasion of host innate immunity...

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PMID: 27025250
DOI: 10.1128/mbio.00258-16

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