Myeloid-derived suppressor cells and T regulatory cells in tumors: unraveling the dark side of the force

Abstract excerpt

Abstract Important conceptual advances in tumor immunology over the last years have shifted the paradigm from focusing on the malignant cell to the importance of host immune components in the design of successful immunotherapies. The immune system, through sophisticated innate and adaptive immune surveillance mechanisms, inhibits the growth and establishment of tumors. However, despite immune surveillance, tumors...

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