Article
Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current.
Circulation. Arrhythmia and electrophysiology - 1 Jan 2016
Nakano Yukiko, Ochi Hidenori, Onohara Yuko, Toshishige Masaaki, Tokuyama Takehito, Matsumura Hiroya, Kawazoe Hiroshi, Tomomori Shunsuke, Sairaku Akinori, Watanabe Yoshikazu, Ikenaga Hiroki, Motoda Chikaaki, Suenari Kazuyoshi, Hayashida Yasufumi, Miki Daiki, Oda Nozomu, Kishimoto Shinji, Oda Noboru, Yoshida Yukihiko, Tashiro Satoshi, Chayama Kazuaki, Kihara Yasuki
Abstract excerpt
BACKGROUND: Risk stratification of Brugada syndrome (BrS) remains controversial and the majority of patients with BrS have no genetic explanation. We investigated relationships between genotypes of 3 single-nucleotide polymorphisms reported in a recent genome-wide association study and BrS phenotypes. METHODS AND RESULTS: SCN10A (rs10428132), SCN5A (rs11708996), and downstream from HEY2 (rs9388451)...
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