The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.

doi:10.1161/CIRCRESAHA.117.310959

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Article

The Brugada Syndrome Susceptibility Gene HEY2 Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.

Circulation research - 18 Aug 2017

Veerman Christiaan C, Podliesna Svitlana, Tadros Rafik, Lodder Elisabeth M, Mengarelli Isabella, de Jonge Berend, Beekman Leander, Barc Julien, Wilders Ronald, Wilde Arthur A M, Boukens Bastiaan J, Coronel Ruben, Verkerk Arie O, Remme Carol Ann, Bezzina Connie R

Abstract excerpt

RATIONALE: Genome-wide association studies previously identified an association of rs9388451 at chromosome 6q22.3 (near HEY2) with Brugada syndrome. The causal gene and underlying mechanism remain unresolved. OBJECTIVE: We used an integrative approach entailing transcriptomic studies in human hearts and electrophysiological studies in Hey2+/- (Hey2 heterozygous knockout) mice to dissect the underpinnings of the...

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PMID: 28637782
DOI: 10.1161/CIRCRESAHA.117.310959

Genes

HEY2
KCNIP2

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