Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registry.

doi:10.1161/CIRCGEN.119.002797

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Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registry.

Circulation. Genomic and precision medicine - 1 Aug 2020

Jimmy Juang Jyh-Ming, Liu Yen-Bin, Julius Chen Ching-Yu, Yu Qi-You, Chattopadhyay Amrita, Lin Lian-Yu, Chen Wen-Jone, Yu Chih-Chien, Huang Hui-Chun, Ho Li-Ting, Lai Ling-Ping, Hwang Juey-Jen, Lin Ting-Tse, Liao Min-Tsun, Chen Jien-Jiun, Sherri Yeh Shih-Fan, Chuang Jing-Yuan, Yang Dun-Hui, Lin Jiunn-Lee, Lu Tzu-Pin, Chuang Eric Y, Ackerman Michael J

Abstract excerpt

BACKGROUND: Brugada syndrome (BrS) is an oligogenic arrhythmic disease with increased risk of sudden cardiac arrest. Several BrS or ECG traits-related single-nucleotide polymorphisms (SNPs) were identified through previous genome-wide association studies in white patients. We aimed to validate these SNPs in BrS patients in the Taiwanese population, assessing the cumulative effect of risk alleles and the...

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PMID: 32490690
DOI: 10.1161/CIRCGEN.119.002797
PMCID: PMC7439932

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