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Article

Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis.

Critical care (London, England) - 2 Jan 2014

Jabandziev Petr, Smerek Michal, Michalek Jaroslav, Fedora Michal, Kosinova Lucie, Hubacek Jaroslav A, Michalek Jaroslav

Abstract excerpt

INTRODUCTION: The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis. METHODS: We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock...

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Topics

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Share to Child, Preschool
Share to Epistasis, Genetic
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Share to Infant, Newborn
Share to Predictive Value of Tests
Share to Sepsis
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Source

Open in PubMed Open full text

Identifiers

PMID: 24383711
DOI: 10.1186/cc13174
PMCID: PMC4056441

Genes

BPI
LBP
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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