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Article

An impaired inflammatory cytokine response to gram-negative LPS in human neonates is associated with the defective TLR-mediated signaling pathway.

Journal of clinical immunology - 1 Feb 2015

Li Yi Ping, Yu Sheng Lin, Huang Zhi Jian, Huang Jie, Pan Jian, Feng Xing, Zhang Xue Guang, Wang Jiang Huai, Wang Jian

Abstract excerpt

PURPOSE: Human neonates are highly susceptible to a wide range of infections, which has been attributed to deficiencies in their innate and adaptive immunity. In contrast to the well-documented immaturity in neonatal adaptive immunity, deficiencies in their innate immunity are less defined. This study examined the inflammatory response of neonatal monocytes to bacterial lipopolysaccharide (LPS) and peptidoglycan...

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Share to Gram-Negative Bacteria
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharide Receptors

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Share to p38 Mitogen-Activated Protein Kinases

Share to Toll-Like Receptor 2

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Source

Identifiers

PMID: 25631527
DOI: 10.1007/s10875-015-0128-6

Genes

TLR4
TLR2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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