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Article

AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression.

Scientific reports - 5 Jan 2016

Peng Yunqian, Kim Ji-Min, Park Hal-Sol, Yang Annie, Islam Celia, Lakatta Edward G, Lin Li

Abstract excerpt

Advanced glycation end products (AGEs) are sugar-modified biomolecules that accumulate in the body with advancing age, and are implicated in the development of multiple age-associated structural and functional abnormities and diseases. It has been well documented that AGEs signal via their receptor RAGE to activate several cellular programs including NF-κB, leading to inflammation. A large number of stimuli can...

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Share to Chromatin Immunoprecipitation
Share to Collagen Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Knockout Techniques

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Source

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Identifiers

PMID: 26729520
DOI: 10.1038/srep18822
PMCID: PMC4700418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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