Article

BMAL1/REV-ERBα loop as a novel inflammatory sensor to drive NF-κB-mediated inflammation in vascular smooth muscle cells by modulating oxidative stress

2024-05-09

Abstract excerpt

<title>Abstract</title> <p>Objectives and design: As a pleiotropic inflammatory cytokine, TNF-α could act as a kind of zeitgeber mediator to integrate with circadian clock and modulate inflammatory signaling. We aimed to investigate how circadian gene <italic>Bmal1</italic> regulating inflammation in vascular smooth muscle cells (VSMCs) upon TNF-α stimulation. Methods Circadian rhythmicity of <italic>Bmal1</ita...

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Literature Corpus work: e35b0695-f0da-5369-93dc-46674db4c361
DOI: 10.21203/rs.3.rs-4353009/v1

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