Article
Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.
Nature communications - 5 Jan 2016
Laumont Céline M, Daouda Tariq, Laverdure Jean-Philippe, Bonneil Éric, Caron-Lizotte Olivier, Hardy Marie-Pierre, Granados Diana P, Durette Chantal, Lemieux Sébastien, Thibault Pierre, Perreault Claude
Abstract excerpt
In view of recent reports documenting pervasive translation outside of canonical protein-coding sequences, we wished to determine the proportion of major histocompatibility complex (MHC) class I-associated peptides (MAPs) derived from non-canonical reading frames. Here we perform proteogenomic analyses of MAPs eluted from human B cells using high-throughput mass spectrometry to probe the six-frame translation of...
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