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Article

Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer-Derived Cells.

Journal of cellular biochemistry - 1 Aug 2016

Kral Rosana, Doriguzzi Angelina, Mayer Christoph-Erik, Krenbek Dagmar, Setinek Ulrike, Sutterlüty-Fall Hedwig

Abstract excerpt

Sprouty2 is a modulator of receptor tyrosine kinase-mediated signalling with an important role during lung carcinogenesis. Here, we characterize a Sprouty2 variant harbouring a substitution of proline 106 with serine. Serine substitution fails to influence expression, but accumulation of slower migrating phosphatase-sensitive forms indicates that its presence facilitates phosphorylation. In normal lung cells the...

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PMID: 26727965
DOI: 10.1002/jcb.25482

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