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Article

Molecular mechanism of Ras-related protein Rab-5A and effect of mutations in the catalytically active phosphate-binding loop.

Journal of biomolecular structure & dynamics - 1 Jan 2017

Khan Faez Iqbal, Aamir Mohd, Wei Dong-Qing, Ahmad Faizan, Hassan Md Imtaiyaz

Abstract excerpt

Ras-related protein (Rab-5a) is primarily involved in the regulation of early endosome fusion during endocytosis and takes part in the budding process. During GTP hydrolysis, Rab5a was spotted in the cytoplasmic side of early endosomes in association with the GTP. Previous study suggested that the substitution of alanine with proline at position 30 of Rab5a reduces the GTPase activity around 12-fold, while, with...

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PMID: 26727234
DOI: 10.1080/07391102.2015.1134346

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