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Article

Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas.

PloS one - 1 Jan 2020

Sharma Neeru, Sonavane Uddhavesh, Joshi Rajendra

Abstract excerpt

The Ras family of proteins is known to play an important role in cellular signal transduction. The oncoprotein Ras is also found to be mutated in ~90% of the pancreatic cancers, of which G12V, G13V, A59G and Q61L are the known hot-spot mutants. These ubiquitous proteins fall in the family of G-proteins, and hence switches between active GTP bound and inactive GDP bound states, which is hindered in most of its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33064725
DOI: 10.1371/journal.pone.0234836
PMCID: PMC7567374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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