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Article

Insight into the molecular switch mechanism of human Rab5a from molecular dynamics simulations.

Biochemical and biophysical research communications - 18 Dec 2009

Wang Jing-Fang, Chou Kuo-Chen

Abstract excerpt

Rab5a is currently a most interesting target because it is responsible for regulating the early endosome fusion in endocytosis and possibly the budding process. We utilized longtime-scale molecular dynamics simulations to investigate the internal motion of the wild-type Rab5a and its A30P mutant. It was observed that, after binding with GTP, the global flexibility of the two proteins is increasing, while the...

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Source

Identifiers

PMID: 19819222
DOI: 10.1016/j.bbrc.2009.10.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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