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Article

The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Feb 2018

Gao Yujing, Wilson Gabrielle R, Stephenson Sarah E M, Bozaoglu Kiymet, Farrer Matthew J, Lockhart Paul J

Abstract excerpt

The identification of pathogenic mutations in Ras analog in brain 39B (RAB39B) and Ras analog in brain 32 (RAB32) that cause Parkinson's disease (PD) has highlighted the emerging role of protein trafficking in disease pathogenesis. Ras analog in brain (Rab) Guanosine triphosphatase (GTPase) function as master regulators of membrane trafficking, including vesicle formation, movement along cytoskeletal networks,...

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Identifiers

PMID: 29315801
DOI: 10.1002/mds.27270

Genes

RAB32

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