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Article

Differentiating the pre-hydrolysis states of wild-type and A59G mutant HRas: An insight through MD simulations.

Computational biology and chemistry - 1 Aug 2017

Sharma Neeru, Sonavane Uddhavesh, Joshi Rajendra

Abstract excerpt

The most representative member of the Ras subfamily is its HRas isoform. Ras proteins being GTPases, possess an intrinsic activity to hydrolyze the GTP molecule to GDP. During the transition phases, between active and inactive states, P-loop and switch regions show maximum variations. Various hot-spot Ras mutants (G12V, A59G, Q61L etc) have been reported, that limit the protein's conformation in the permanent...

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PMID: 28600956
DOI: 10.1016/j.compbiolchem.2017.05.008

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