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Article

The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes.

The Journal of biological chemistry - 19 Mar 2004

Pasqualato Sebastiano, Senic-Matuglia Francesca, Renault Louis, Goud Bruno, Salamero Jean, Cherfils Jacqueline

Abstract excerpt

The small GTP-binding protein Rab11 is an essential regulator of the dynamics of recycling endosomes. Here we report the crystallographic analysis of the GDP/GTP cycle of human Rab11a, and a structure-based mutagenesis study that identifies a novel mutant phenotype. The crystal structures show that the nucleotide-sensitive switch 1 and 2 regions differ from those of other Rab proteins. In Rab11-GDP, they...

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PMID: 14699104
DOI: 10.1074/jbc.M310558200

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EEA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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