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Article

A comparison between similarity matrices for principal component analysis to assess population stratification in sequenced genetic data sets.

Briefings in bioinformatics - 19 Jan 2023

Lee Sanghun, Hahn Georg, Hecker Julian, Lutz Sharon M, Mullin Kristina, Hide Winston, Bertram Lars, DeMeo Dawn L, Tanzi Rudolph E, Lange Christoph, Prokopenko Dmitry

Abstract excerpt

Genetic similarity matrices are commonly used to assess population substructure (PS) in genetic studies. Through simulation studies and by the application to whole-genome sequencing (WGS) data, we evaluate the performance of three genetic similarity matrices: the unweighted and weighted Jaccard similarity matrices and the genetic relationship matrix. We describe different scenarios that can create numerical...

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Identifiers

PMID: 36585781
DOI: 10.1093/bib/bbac611
PMCID: PMC9851291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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