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Article

OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway.

The Journal of biological chemistry - 26 Feb 2016

Seaayfan Elie, Defontaine Nadia, Demaretz Sylvie, Zaarour Nancy, Laghmani Kamel

Abstract excerpt

Mutations in the renal specific Na-K-2Cl co-transporter (NKCC2) lead to type I Bartter syndrome, a life-threatening kidney disease featuring arterial hypotension along with electrolyte abnormalities. We have previously shown that NKCC2 and its disease-causing mutants are subject to regulation by endoplasmic reticulum-associated degradation (ERAD). The aim of the present study was to identify the protein partners...

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Identifiers

PMID: 26721884
DOI: 10.1074/jbc.M115.702514
PMCID: PMC4813476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway.PMID 26721884Read ↗

New insights into the role of endoplasmic reticulum-associated degradation in Bartter Syndrome Type 1.Semantic proximity Read ↗

A highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2.Semantic proximity Read ↗

Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2.Semantic proximity Read ↗

Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2.Semantic proximity Read ↗

Regulation of the Na-K-2Cl cotransporter NKCC2 by ubiquitylationSemantic proximity Read ↗

Nephrin binds to the COOH terminus of a large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel isoform and regulates its expression on the cell surfaceSemantic proximity Read ↗

Exon Loss Accounts for Differential Sorting of Na-K-Cl Cotransporters in Polarized Epithelial CellsSemantic proximity Read ↗

Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA.Semantic proximity Read ↗

NKCC2 activity is inhibited by the Bartter's syndrome type 5 gain-of-function CaR-A843E mutant in renal cells.Semantic proximity Read ↗

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.Semantic proximity Read ↗

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.Semantic proximity Read ↗

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.Semantic proximity Read ↗

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