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Article

Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA.

The Journal of biological chemistry - 20 May 2011

Sweadner Kathleen J, Pascoa Jennifer L, Salazar Cynthia A, Arystarkhova Elena

Abstract excerpt

In kidney, FXYD proteins regulate Na,K-ATPase in a nephron segment-specific way. FXYD2 is the most abundant renal FXYD but is not expressed in most renal cell lines unless induced by hypertonicity. Expression by transfection of FXYD2a or FXYD2b splice variants in NRK-52E cells reduces the apparent Na(+) affinity of the Na,K-ATPase and slows the cell proliferation rate. Based on RT-PCR, mRNAs for both splice...

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Identifiers

PMID: 21460224
DOI: 10.1074/jbc.M111.241901
PMCID: PMC3093901

Genes

FXYD2
NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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