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Nephrin binds to the COOH terminus of a large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel isoform and regulates its expression on the cell surface

15 May 2008

Abstract excerpt

We carried out a yeast two-hybrid screen to identify proteins that interact with large-conductance Ca2+-activated K+ (BKCa) channels encoded by the Slo1 gene. Nephrin, an essential adhesion and scaffolding molecule expressed in podocytes, emerged in this screen. The Slo1-nephrin interaction was confirmed by coimmunoprecipitation from the brain and kidney, from HEK-293T cells expressing both proteins, and by...

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Identifiers

PMID: 18480178
DOI: 10.1152/ajprenal.00140.2008

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