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Article

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

The Journal of cell biology - 7 Sept 2009

Stagg Helen R, Thomas Mair, van den Boomen Dick, Wiertz Emmanuel J H J, Drabkin Harry A, Gemmill Robert M, Lehner Paul J

Abstract excerpt

The US2 and US11 gene products of human cytomegalovirus promote viral evasion by hijacking the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. US2 and US11 initiate dislocation of newly translocated major histocompatibility complex class I (MHC I) from the ER to the cytosol for proteasome-mediated degradation, thereby decreasing cell surface MHC I. Despite being instrumental in elucidating the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19720873
DOI: 10.1083/jcb.200906110
PMCID: PMC2742190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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