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Article

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

1 Mar 2015

Abstract excerpt

Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non-homologous end-joining (cNHEJ). Support of cNHEJ involves a mechanism independent of RB1's cell-cycle function and depends on its amino terminal domain with which it...

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PMID: 25818292
DOI: 10.1016/j.celrep.2015.02.059

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