Article
Integrated molecular profiling of juvenile myelomonocytic leukemia.
Blood - 5 Apr 2018
Murakami Norihiro, Okuno Yusuke, Yoshida Kenichi, Shiraishi Yuichi, Nagae Genta, Suzuki Kyogo, Narita Atsushi, Sakaguchi Hirotoshi, Kawashima Nozomu, Wang Xinan, Xu Yinyan, Chiba Kenichi, Tanaka Hiroko, Hama Asahito, Sanada Masashi, Ito Masafumi, Hirayama Masashi, Watanabe Arata, Ueno Toshihide, Kojima Seiji, Aburatani Hiroyuki, Mano Hiroyuki, Miyano Satoru, Ogawa Seishi, Takahashi Yoshiyuki, Muramatsu Hideki
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML), a rare and aggressive myelodysplastic/myeloproliferative neoplasm that occurs in infants and during early childhood, is characterized by excessive myelomonocytic cell proliferation. More than 80% of patients harbor germ line and somatic mutations in RAS pathway genes (eg, PTPN11, NF1, NRAS, KRAS, and CBL), and previous studies have identified several biomarkers associated...
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