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Article

[Juvenile myelomonocytic leukemia (JMML): recent advances in molecular pathogenesis and treatment].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Feb 2016

Sakashita Kazuo

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative disorder that occurs during infancy and early childhood; this disorder is characterized by hypersensitivity of the myeloid progenitor cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) in vitro. JMML usually involves somatic and/or germline mutations in the genes of the RAS pathway, including PTPN11, NRAS, KRAS,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelomonocytic, Juvenile

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Source

Identifiers

PMID: 26935631
DOI: 10.11406/rinketsu.57.137

Genes

CBL
KRAS
NRAS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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