Article
Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2.
PloS one - 1 Jan 2012
Lu Pinyi, Hontecillas Raquel, Horne William T, Carbo Adria, Viladomiu Monica, Pedragosa Mireia, Bevan David R, Lewis Stephanie N, Bassaganya-Riera Josep
Abstract excerpt
BACKGROUND: Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the eukaryotic lanthionine synthetase component C-Like protein family involved in signal transduction and insulin sensitization. Recently, LANCL2 is a target for the binding and signaling of abscisic acid (ABA), a plant hormone with anti-diabetic and anti-inflammatory effects. METHODOLOGY/PRINCIPAL FINDINGS: The goal of this...
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