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Mystery machine: the complex roles of NLRX1 in viral infection

28 Apr 2025

Abstract excerpt

Effective antiviral immunity requires a delicate balance between controlling infection and preventing excessive inflammation. NLRX1, an atypical member of the NOD-like receptor family, plays a crucial regulatory role in this process by modulating immune responses to both RNA and DNA viruses. Unlike other NLRs, NLRX1 does not directly activate inflammatory pathways, but rather fine tunes immune responses through...

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PMID: 40356929
DOI: 10.3389/fimmu.2025.1581313

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