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Article

A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.

Molecular and cellular biology - 28 Dec 2015

Mir Riyaz A, Bele Aditya, Mirza Sameer, Srivastava Shashank, Olou Appolinaire A, Ammons Shalis A, Kim Jun Hyun, Gurumurthy Channabasavaiah B, Qiu Fang, Band Hamid, Band Vimla

Abstract excerpt

Ecdysoneless (ECD) is an evolutionarily conserved protein whose germ line deletion is embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by exogenous ECD, demonstrating a requirement of ECD for normal mammalian cell cycle progression. However, the exact mechanism by which ECD regulates cell cycle is unknown. Here, we demonstrate that ECD protein levels and subcellular...

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Identifiers

PMID: 26711270
DOI: 10.1128/MCB.00594-15
PMCID: PMC4810467

Genes

ECD
RUVBL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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