Article
Regulation of Cellular Signaling by CUL5 is Dependent on Its Neddylation Status.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 9 Mar 2026
Sundquist Skylar, Lee Sieun Ruth, Johnson Alyssa, Lynch Haley M, Schnell Abbey, Wieskamp Sarah, Peabody Henry N, Kennington Lauren, Askonas Caroline, Turner Charlotte, Hayes David, Hledin Michael, Lee Lauren, Burnatowska-Hledin Maria A
Abstract excerpt
BACKGROUND/AIMS: CUL5 acts as the scaffold protein of the E3 ligase complex in ubiquitin-dependent protein degradation pathways. Overexpression of CUL5 inhibits cellular proliferation, whereas inhibition of CUL5 expression induces proliferation and may contribute to clinical disorders including cancer. The effects of CUL5 depend on its post-translational modification by NEDD8 (neddylation), a process that...
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