Article
[ Spectrum of oncogene mutations is different in melanoma subtypes].
Molekuliarnaia biologiia - 1 Jan 2000
Mazurenko N N, Tsyganova I V, Lushnikova A A, Ponkratova D A, Anurova O A, Cheremushkin E A, Mikhailova I N, Demidov L V
Abstract excerpt
Melanoma is the most lethal malignancy of skin, which is comprised of clinically relevant molecular subsets defined by specific "driver" mutations in BRAF, NRAS, and KIT genes. Recently, the better results in melanoma treatment were obtained with the mutation-specific inhibitors that have been developed for clinical use and target only patients with particular tumor genotypes. The aim of the study was to...
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