Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Molecular heterogeneity of malignant melanomas].

Der Pathologe - 1 Nov 2007

Glatz K

Abstract excerpt

Malignant melanomas make up a heterogeneous group of tumors characterized by particular genetic aberrations depending on their anatomic localization and UV exposure. Activation of the mitogen-activated protein kinase (MAPK) signaling pathway is found in the majority of melanomas, with either somatic missense mutations of BRAF or, considerably more rarely, mutations of N-RAS. The loss of both products of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Diagnosis, Differential
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Phosphatidylinositol 3-Kinases

Share to Signal Transduction

Share to Skin Neoplasms

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 17885757
DOI: 10.1007/s00292-007-0942-6

Genes

BRAF
KIT
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Molecular heterogeneity of malignant melanomas].PMID 17885757Read ↗

[Molecular classification and markers of malignant melanoma].Semantic proximity Read ↗

[Molecular alterations in melanoma and targeted therapies].Semantic proximity Read ↗

[ Spectrum of oncogene mutations is different in melanoma subtypes].Semantic proximity Read ↗

[Clinical and biological heterogeneity of melanomas].Semantic proximity Read ↗

[New insights on genetics of malignant melanoma].Semantic proximity Read ↗

[Genetic diversity and immunological characteristics of malignant melanoma: the therapeutic spectrum].Semantic proximity Read ↗

[Ⅰ. Genomic Alterations of Melanoma].Semantic proximity Read ↗

[Melanoma: from molecular studies to the treatment breakthrough].Semantic proximity Read ↗

BRAF alterations are associated with complex mutational profiles in malignant melanoma.Semantic proximity Read ↗

Molecular and genetic mechanisms in melanoma.Semantic proximity Read ↗

Molecular pathogenesis of cutaneous melanocytic neoplasms.Semantic proximity Read ↗

[New therapies targeting the genetic mutations responsible for different types of melanoma].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.