[Melanoma: from molecular studies to the treatment breakthrough].

Abstract excerpt

Melanoma holds a leading position in the mortality from skin tumors. Standard treatment of metastatic melanoma allows tumor remission to be achieved only in a small subset of patients. Studies on melanoma molecular pathogenesis led to the identification of several causative genetic events and, consequently, to the development of novel targeted drugs. More than a half of melanomas contain amine acid substitutions...

Topics

• Benzamides
• Clinical Trials as Topic
• Humans
• Imatinib Mesylate
• Imidazoles
• Indoles
• Melanoma
• Molecular Targeted Therapy
• Mutation
• Oximes
• Piperazines
• Proto-Oncogene Proteins B-raf