DNA damage in IDH-mutant gliomas: mechanisms and clinical implications.

Abstract excerpt

PURPOSE: Since the discovery of IDH mutations in glioma over a decade ago, significant progress has been made in determining how these mutations affect epigenetic, transcriptomic, and metabolic programs in brain tumor cells. In this article, we summarize current understanding of how IDH mutations influence DNA damage in glioma and discuss clinical implications of these findings. METHODS: We performed a thorough...

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• Brain Neoplasms
• Carcinogens and Genotoxicity Assessment
• DNA Damage
• DNA Repair Mechanisms
• Glioma