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Article

MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance.

Journal of molecular neuroscience : MN - 1 Apr 2016

García-Gómez Beatriz E, Fernández-Gómez Francisco J, Muñoz-Delgado Encarnación, Buée Luc, Blum David, Vidal Cecilio J

Abstract excerpt

The microtubule-associated protein Tau tends to form aggregates in neurodegenerative disorders referred to as tauopathies. The tauopathy model transgenic (Tg) THY-Tau22 (Tau22) mouse shows disturbed septo-hippocampal transmission, memory deficits and no signs of motor dysfunction. The reports showing a hippocampal downregulation of choline acetyltransferase (ChAT) in SAMP8 mice, a model of aging, and an...

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Identifiers

PMID: 26697857
DOI: 10.1007/s12031-015-0699-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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