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Article

Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice.

Neuroscience research - 1 Feb 2009

Jazi R, Lalonde R, Qian S, Strazielle C

Abstract excerpt

Human presenilin-1 (PS1) mutations are a major cause of autosomal dominant Alzheimer's disease. Forebrain cholinergic innervation was estimated in transgenic mice with the A246E mutation by measuring the activity of the non-specific catabolic enzyme, acetylcholinesterase (AChE). In the model, Abeta(42) concentrations increase without neuritic plaques or cell degeneration. PS1/A246E transgenic mice had altered...

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Identifiers

PMID: 19056437
DOI: 10.1016/j.neures.2008.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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