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Article

Overexpression of Telomerase Reverse Transcriptase Induces Autism-like Excitatory Phenotypes in Mice.

Molecular neurobiology - 1 Dec 2016

Kim Ki Chan, Rhee Jeehae, Park Jong-Eun, Lee Dong-Keun, Choi Chang Soon, Kim Ji-Woon, Lee Han-Woong, Song Mi-Ryoung, Yoo Hee Jeong, Chung ChiHye, Shin Chan Young

Abstract excerpt

In addition to its classical role as a regulator of telomere length, recent reports suggest that telomerase reverse transcriptase (TERT) plays a role in the transcriptional regulation of gene expression such as β-catenin-responsive pathways. Silencing or over-expression of TERT in cultured NPCs demonstrated that TERT induced glutamatergic neuronal differentiation. During embryonic brain development, expression of...

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PMID: 26696493
DOI: 10.1007/s12035-015-9630-3

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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